Topical chicken protein to treat type 1 diabetes? The immunological basis explained …
Strange idea? May not be for people familiar with food allergy treatment.
Peanut protein patch applied to HEALTHY skin is a treatment for peanut allergy.
One of the ways peanut protein applied to skin works, is the generation of regulatory T cells (Tregs) specific to peanut.
Tregs regulate/moderate the immune system's reaction to peanut exposure.
One of the causes for type 1 diabetes (T1D) is a reduction in the number of Tregs in the pancreas. This allows CD8+ T cells to attack the islet cells, unrestrained, causing T1D.
Why chicken soup?
As explained in the articles below, chicken protein is the most likely source of
the proteins that train the CD8+ T cells to attack the islet cells. We need chicken protein specific Tregs to restrain them.
The potential solution is to create chicken protein specific Tregs by topical chicken soup.
Why topical and not drinking/eating chicken soup?
Tregs are trained to home to a part of the body.
Eating/drinking chicken soup generates Tregs that home to the gut.
Topical chicken soup generates Tregs that home to the skin.
As described in the articles above, the CD8+ T cells that attack islet cells are trained to home to the skin. But it turns out the pancreas attract these cells by producing the same chemical attractant as the skin.
Therefore skin homing Tregs produced by topical chicken soup will also home to the pancreas just like the CD8+ T cells.
Going by the peanut patch experience, it could take up to a year to see the effect … if it works.
IMPORTANT: Never apply food proteins to damaged skin, only to HEALTHY skin.
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